Energy matters: mitochondrial proteomics for biomedicine |
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Authors: | Gianazza Elisabetta Eberini Ivano Sensi Cristina Barile Maria Vergani Lodovica Vanoni Maria Antonietta |
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Institution: | Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, Milano, Italy. elisabetta.gianazza@unimi.it |
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Abstract: | This review compiles results of medical relevance from mitochondrial proteomics, grouped either according to the type of disease - genetic or degenerative - or to the involved mechanism - oxidative stress or apoptosis. The findings are commented in the light of our current understanding of uniformity/variability in cell responses to different stimuli. Specificities in the conceptual and technical approaches to human mitochondrial proteomics are also outlined. |
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