Analysis of polymorphisms in the insulin-like growth factor 1 receptor (IGF1R) gene from Japanese quail selected for body weight |
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Authors: | Moe H H Shimogiri T Kamihiraguma W Isobe H Kawabe K Okamoto S Minvielle F Maeda Y |
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Affiliation: | The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan;. Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan;. Frontier Science Research Center, Kagoshima University, Kagoshima 890-0065, Japan;. UMR1236 INRA/INA-PG Génétique et DiversitéAnimales, Jouy en Josas 78350, France |
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Abstract: | Insulin-like growth factor 1 receptor ( IGF1R ) is essential for the signalling of growth. In this study, we performed single nucleotide polymorphism (SNP) detection in the Japanese quail IGF1R coding region and an association study between SNPs and body weight in two lines (SS and LL) selected for large and small body weight. Of 21 SNPs obtained, a SNP at position AB292766:c.2293G>A led to the replacement of a valine with an isoleucine (V765I). The two lines were fixed for alternate alleles, with allele encoding valine fixed in the LL line. A significant effect of the SNP genotype was found on 10-week body weight ( P < 0.01) and on 4- to 10-week and 6- to 10-week average daily gain ( P < 0.05) in the F2 family obtained from lines LL and SS. In six populations maintained in Japan or France, the frequency of allele encoding valine was higher than the allele encoding isoleucine. |
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Keywords: | growth insulin-like growth factor 1 receptor Japanese quail single nucleotide polymorphism |
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