Daily changes of free serum tryptophan in humans |
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| Authors: | A Tagliamonte R Gessa G Biggio L Vargiu G L Gessa |
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| Affiliation: | Institute of Pharmacology, University of Cagliari, Italy |
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| Abstract: | In normal subjects the concentration of free tryptophan in serum was about 45% higher at midnight than at noon. However, total concentration of tryptophan in serum showed no significant change. Since previous experiments in rats indicated that free serum tryptophan reflects the rate of brain serotonin synthesis, the present results suggest that in humans, brain serotonin synthesis is greater at midnight that at noon. |
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