| 腹腔注射LPS 对大鼠海马nNOS 和iNOS 表达的影响 |
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| 引用本文： | 钟,萍,吴丹红.腹腔注射LPS 对大鼠海马nNOS 和iNOS 表达的影响[J].现代生物医学进展,2006,6(7):29-30. |
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| 作者姓名： | 钟 萍 吴丹红 |
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| 作者单位： | 1. 上海市中西医结合医院神经内科,上海,200082
2. 上海市交通大学附属第三人民医院神经科,上海,201900 |
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| 摘 要： | 目的：探讨外周免疫刺激对大鼠海马nNOS和iNOS表达的影响。方法：腹腔注射LPS600μg／kg建立免疫激发大鼠模型,对照组注射等量的生理盐水,2．5h后用RT—PCR技术,观察两组大鼠海马nNOS mRNA和iNOS mRNA的表达变化,检测OD值并进行统计学分析。结果：腹腔注射LPS组大鼠海马的nNOS和iNOS的mRNA水平较对照组高。结论：海马在大鼠机体的免疫应激反应中起重要调节作用,iNOS和nNOS来源的N0是该调节过程中的重要信使分子。
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| 关 键 词： | "海马" "一氧化氮合酶" "细菌脂多糖" |
| 收稿时间： | 2006-04-17 |
| 修稿时间： | 2006-05-20 |
Effects of intraperitoneal injection of LPS on expression of nNOS and iNOS in rats hippocampus |
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| ZHONG Ping,WU Dan- hong.Effects of intraperitoneal injection of LPS on expression of nNOS and iNOS in rats hippocampus[J].Progress in Modern Biomedicine,2006,6(7):29-30. |
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| Authors: | ZHONG Ping WU Dan- hong |
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| Abstract: | Objective: To investigate the effects of peripheral immune stimulation on expression of nNOS and iNOS in rats hippocampus.Methods: Rats of experiment group were intraperitoneally injected LPS,control rats were treated by saline.2.5h after treatment,RT-PCR was used to observe the expression of nNOS mRNA and iNOS mRNA.After their OD value was detected,we make statistic analyses.Results: The level of nNOS mRNA and iNOS mRNA in LPS treated rats hippocampus were increased more obviously than that in control rats.Conclusion: Rats Hippocampus plays an important role in its immunomodulation process in which NO made by nNOS and iNOS acts as one of important signal molecules. |
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| Keywords: | "LPS" "hipcampus" "NOS" |
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