| Abstract: | The metabolism of 2-amino-3-phosphono-2-(14)C]propionic acid or 2-amino-3-phosphono-3-(14)C]propionic acid in rats was studied in vivo and in vitro. The radioactivity in expired CO2 from the 3-(14)C]-labelled compound indicated the cleavage of the carbon-phosphorus (C-P) bond. A small amount of the 2-(14)C]-labelled compound and the 3-(14C]-labelled compound was incorporated into 2-aminoethylphosphonic acid, and polar lipid of the liver and kidney contained the 2-aminoethylphosphonic acid. The 2-amino-3-phosphonopropionic acid was not detected at the lipid level. Incorporation of the 3-(14)C]-labelled compound into a variety of metabolites including 3-phosphonopyruvic acid and 2-phosphonoacetaldehyde suggests the transamination reaction as a decomposition mechanism of 2-amino-3-phosphonopropionic acid in mammals. |
