Effect of hypophysectomy and growth hormone replacement on hypothalamic GHRH |
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Authors: | I. Ganzetti V. De Gennaro M. Redaelli E. E. Mü ller D. Cocchi |
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Affiliation: | Department of Pharmacology, Chemotherapy and Toxicology, University of Milan 20129, Italy |
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Abstract: | Long-term (7 and 14 days) hypophysectomy resulted in a striking decrease in growth hormone releasing hormone-like immunoreactivity (GHRH-LI) in the median eminence (ME) of adult male rats, evaluated by both radioimmunoassay and immunohistochemistry. Treatment with human GH (125 μg/rat, twice daily IP for 14 days) prevented, though partially, depletion of GHRH-LI from the ME, as assessed by both methods. These results demonstrate that circulating GH levels regulate the function of GHRH-producing structures, via a feedback mechanism. |
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Keywords: | Hypophysectomy Growth hormone Growth hormone-releasing hormone Immunohistochemistry |
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