A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell |
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| Authors: | S Papa F Guerrieri N Capitanio |
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| Institution: | (1) Institute of Medical Biochemistry and Chemistry Medical Faculty, University of Bari, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy |
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| Abstract: | Evidence is available showing that the coupling efficiency of the proton pump in cytochrome c oxidase of mitochondria can under certain conditions decrease significantly below the maximum attainable value. The view is developed that slips in the proton pump of cytochrome c oxidase represent an intrinsic switch mechanism which regulates the relative contribution of energy transfer and respiratory protection against oxygen toxicity by the oxidase. |
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| Keywords: | Cytochrome c oxidase proton pumps reactive oxygen species respiratory protection |
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