Prostaglandins and congeners IX (1). The synthesis of 15-deoxy-16-, 17-, or 20-hydroxyprostaglandins and 15-deoxy-15-hydroxymethylprostaglandin E2 |
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| Authors: | M Brawner Floyd Robert E Schaub Martin J Weiss |
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| Institution: | Metabolic Disease Therapy Research Section, Lederle Laboratories American Cyanamid Company, Pearl River, New York 10965, USA |
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| Abstract: | Prostaglandin congeners wherein the 15-hydroxy group is moved to the C16, C17, or C20 position or is replaced by a hydroxymethyl group were prepared via the 1,4-addition of a lithium trialkyl-trans-alkenyl alanate to an appropriate cyclopentenone. Several of the 16-hydroxy derivatives showed significant activity as constrictors of the isolated gerbil colon and in bronchodilator and anti-secretory assays. |
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