| ATM、ATR和DNA损伤介导的细胞周期阻滞 |
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| 引用本文： | 朱虹,缪泽鸿,丁健.ATM、ATR和DNA损伤介导的细胞周期阻滞[J].生命科学,2007,19(2):139-148. |
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| 作者姓名： | 朱虹 缪泽鸿 丁健 |
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| 作者单位： | 中国科学院上海生命科学研究院药物研究所新药研究国家重点实验室,上海,201203 |
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| 基金项目： | 中国科学院知识创新工程项目 |
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| 摘 要： | ATM和ATR属于PIKK家族,是DNA损伤检查点的主要成员。它们被不同类型的DNA损伤所激活,通过磷酸化相应的下游蛋白Chk1和Chk2等,调节细胞周期各个检查点,引起细胞周期阻滞,使DNA损伤得以修复。ATM和ATR在维持基因组的稳定性中起到至关重要的作用。本文着重综述有关ATM和ATR在DNA损伤介导的细胞周期阻滞中发挥的作用以及相互关系的最新研究进展。
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| 关 键 词： | DNA损伤 细胞周期检查点 细胞周期阻滞 |
| 文章编号： | 1004-0374（2007）02-0139-10 |
| 收稿时间： | 2006-12-07 |
| 修稿时间： | 2006-12-31 |
ATM, ATR and DNA damage-induced cell cycle arrest |
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| ZHU Hong,MIAO Zehong,DING Jian.ATM, ATR and DNA damage-induced cell cycle arrest[J].Chinese Bulletin of Life Sciences,2007,19(2):139-148. |
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| Authors: | ZHU Hong MIAO Zehong DING Jian |
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| Institution: | Shanghai Institute of Matefia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | ATM and ATR,two major members of PIKK family,play central roles in cellular response to DNA damage and replication stress.Once activated by DNA damage,they phosphorylate a number of substrates such as Chkl and Chk2,which in turn target other proteins to induce cell cycle arrest and facilitate DNA repair. ATM and ATR are indispensable for maintaining genome integrity.Many studies have been done to make further understanding of mechanisms of ATM and ATR.This review mainly focuses on the roles they play in DNA damage-mediated cell cycle arrest,and the crosstalk of these two protein kinases. |
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| Keywords: | ATM ATR |
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