Pigment epithelium-derived factor (PEDF) prevents advanced glycation end products (AGEs)-elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties |
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| Authors: | Yamagishi Sho-ichi Ueda Seiji Matsui Takanori Nakamura Kazuo Imaizumi Tsutomu Takeuchi Masayoshi Okuda Seiya |
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| Institution: | Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Japan. shoichi@med.kurume-u.ac.jp |
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| Abstract: | PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis. |
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