Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety |
| |
| Authors: | Karthikeyan Mari Sithambaram Prasad Dasappa Jagadeesh Poojary Boja Subrahmanya Bhat K Holla Bantwal Shivarama Kumari Nalilu Suchetha |
| |
| Institution: | Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com |
| |
| Abstract: | A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
