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Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2 |
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| Authors: | Zakaria Rachid Meaghan MacPhee Christopher Williams Margarita Todorova Bertrand Jacques Jean-Claude |
| Institution: | aCancer Drug Research Laboratory, Division of Medical Oncology, Department of Medicine, McGill University/Royal Victoria Hospital, 687 Pine Avenue west Rm M-719, Montreal, Québec, Canada H3A 1A1;bChemical Computing Group Inc., 1010 Sherbrooke Street West, Suite 910, Montreal, Québec, Canada H3A 2R7 |
| Abstract: | The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described. |
| Keywords: | Combi-triazenes EGFR HER2 Quinazoline |
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