Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the Mediterranean ascidian Aplidium conicum |
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| Authors: | Aiello Anna Esposito Giuseppe Fattorusso Ernesto Iuvone Teresa Luciano Paolo Menna Marialuisa |
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| Affiliation: | a Dipartimento di Chimica delle Sostanze Naturali, Via Domenico Montesano 49, 80131 Napoli, Italy
b Dipartimento di Farmacologia Sperimentale, Via Domenico Montesano 49, 80131 Napoli, Italy |
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| Abstract: | Two novel 9,11-secosterols, aplidiasterols A (3β,6β,11-trihydroxy-9,11-seco-5α-cholest-7-en-9-one, 1) and B (3β,5α,6β,11-tetrahydroxy-9,11-secocholest-7-en-9-one, 2), along with the known secosterols 3 and 4, were isolated from the Mediterranean ascidian Aplidium conicum and their structures were determined by spectroscopic data. Aplidiasterols A and B were found to be cytotoxic against rat glioma (C6) and murine monocyte/macrophage (J774) tumor cells in vitro. Compounds 1-4 represent the first example of secosterols isolated from tunicates. |
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| Keywords: | 9,11-Secosterols Ascidians Tunicates Aplidium conicum NMR Cytotoxic agents |
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