Synthesis of 3H-spiro[benzofuran-2,1'-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity |
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| Authors: | Useglio Mariana Castellano Patricia M Operto María A Torres René Kaufman Teodoro S |
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| Institution: | Instituto de Química Orgánica de Síntesis, IQUIOS, CONICET-UNR, and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina. |
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| Abstract: | Six 3H-spirobenzofuran-2,1'-cyclohexane] derivatives were synthesized from naturally occurring filifolinol, and their classical complement pathway inhibitory activity was determined. IC(50) values of the most potent compounds were comparable to the activity of the natural complement inhibitor K76-COOH and some synthetic tricyclic analogs of it. |
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