| 分枝杆菌聚阿拉伯半乳糖的结构和生物合成过程及其应用意义 |
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| 引用本文： | 张文利,马郁芳. 分枝杆菌聚阿拉伯半乳糖的结构和生物合成过程及其应用意义[J]. 现代生物医学进展, 2008, 8(9): 1759-1762 |
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| 作者姓名： | 张文利 马郁芳 |
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| 作者单位： | 1. 大连医科大学生化与分子生物学教研室,辽宁大连,116044
2. 大连医科大学生化与分子生物学教研室,辽宁大连,116044;辽宁省糖生物学与糖工程重点实验室,辽宁大连,116044 |
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| 摘 要： | 聚阿拉伯半乳糖(Arabinogalactan,AG)是分枝杆菌细胞壁的主要组成成分,对于维持分枝杆菌细胞壁的完整具有重要意义。AG由衔接双糖、聚阿拉伯糖及聚半乳糖组成,连接方式各异、结构复杂。AG的合成是以UDP-GlcNAc、dTDP-Rha、UDP-Galf、多聚异戊二烯磷酸阿拉伯糖(DPA)为糖基供体,其中参与糖基供体形成及AG合成的酶是研发抗结核新药的作用靶点,而由此研发出的新药对治疗结核病具有高度专一性且对人类无毒性副作用。
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| 关 键 词： | 结核分枝杆菌 细胞壁 聚阿拉伯半乳糖 |
Structure and Biosynthesis of Arabinogalactan and Its Application in Mycobacteria |
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| ZHANO Wen-li,MA Yu-fang. Structure and Biosynthesis of Arabinogalactan and Its Application in Mycobacteria[J]. Progress in Modern Biomedicine, 2008, 8(9): 1759-1762 |
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| Authors: | ZHANO Wen-li MA Yu-fang |
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| Abstract: | One of the main compositions of mycobacterial cell wall is arabinogalactan (AG), which plays an essential role in the integrity of cell wall and in controlling the growth of the bacteria. The three constituents of AG are linker of L-Rhap-(1-3)-GlcNAc, ara- binanandgalactan. Various types and linkage of sugarunits lead to complicated AG structure.dTDP-Rha, UDP-Galf, DPA were sugar donor in the process of AG biosynthesis. The biosynthesis of AG's constituents and the sugar donors may be the site of action of powerful and potential anti-mycobacterial compound. |
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| Keywords: | M. tuberculosis Cell wall Arabinogalactan(AG) |
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