Estrogen receptor variants and mutations |
| |
Authors: | Leigh C. Murphy Helmut Dotzlaw Etienne Leygue Deborah Douglas Amanda Coutts Peter H. Watson |
| |
Affiliation: | Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, R3E 0W3, Canada |
| |
Abstract: | There is a large and increasing body of experimental and clinical data supporting the existence of variant estrogen receptor (ER) proteins in both normal and neoplastic estrogen target tissues, including human breast. Therefore, future examination of ER signal transduction and/or measurement of ER protein must take into account variant ER expression. The functions of variant ER proteins, either physiological or pathological, remain unclear, although a role(s) for some ER variants in breast tumorigenesis and breast cancer progression would be consistent with the accumulated data. Possible tissue specific expression leads to the speculation that ER variants may have a role in tissue specific estrogen action. The following review focuses on the current knowledge available in the scientific literature with respect to the type and characteristics of estrogen receptor variants and mutations that have been identified to occur naturally in tissues and cell lines. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|