Changes of the hepatic proteome in hepatitis B-infected mouse model at early stages of fibrosis |
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| Authors: | Spano Daniela Cimmino Flora Capasso Mario D'Angelo Fulvio Zambrano Nicola Terracciano Luigi Iolascon Achille |
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| Affiliation: | CEINGE Biotecnologie Avanzate, Napoli, Italy. |
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| Abstract: | Liver fibrosis (LF) is the accumulation of extracellular matrix (ECM) proteins due to chronic liver injury. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to perform a comparative analysis of cytosolic and nuclear protein patterns of nontransgenic (NTg) and HBV transgenic (Tg) mice livers at early stages of fibrosis. We identified several candidate proteins, involved in a variety of pathways, which could be used as putative biomarkers for LF early detection. |
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