M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds |
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| Authors: | Suckling Colin J Murphy John A Khalaf Abedawn I Zhou Sheng-ze Lizos Dimitris E van Nhien Albert Nguyen Yasumatsu Hiroshi McVie Allan Young Louise C McCraw Corinna Waterman Peter G Morris Brian J Pratt Judith A Harvey Alan L |
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| Institution: | Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland, UK. c.j.suckling@strath.ac.uk |
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| Abstract: | Chronic low-dose treatment of rats with the psychomimetic drug, phencyclidine, induces regionally specific metabolic and neurochemical changes in the CNS that mirror those observed in the brains of schizophrenic patients. Recent evidence suggests that drugs targeting serotoninergic and muscarinic receptors, and in particular 5-HT(7) antagonists and M(4) agonists, exert beneficial effects in this model of schizophrenia. Compounds that display this combined pattern of activity we refer to as serominic compounds. Based upon leads from natural product screening, we have designed and synthesised such serominic compounds, which are principally arylamidine derivatives of tetrahydroisoquinolines, and shown that they have the required serominic profile in ligand binding assays and show potential antipsychotic activity in functional assays. |
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