Role of prostaglandin E2 in regulation of urine excretion in saluresis, water and osmotic diuresis in rat |
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Authors: | Bogolepova A E Shakhmatova E I |
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Abstract: | In the saluresis, water and osmotic diuresis were indicating an increase of prostaglandin E2 excretion and a correlation between this index and diuresis. Unselective blockade of cyclooxygenase by diclofenac-natrium leads to a decrease of diuresis in the observed types of urine-production in rats. Inhibition of inducible cyclooxygenase by celebrex didn't change the value of diuresis after water load or administration of osmotic agent, but decreased the diuretic effect of furosemide. |
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