Design of RNA-binding proteins and ligands |
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Authors: | Cheng A C Calabro V Frankel A D |
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Affiliation: | Department of Biochemistry and Biophysics, University of California San Francisco, 94143-0448, USA. frankel@cgl.ucsf.edu |
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Abstract: | The rapidly expanding database of RNA structures and protein complexes is beginning to lead to the successful design of specific RNA-binding molecules. Recent combinatorial and structure-based approaches have utilized known nucleic-acid-binding scaffolds from both proteins and small molecules to display a relatively small set of functional groups often used in protein--RNA recognition. Several studies have shown that the tethering of multiple binding modules can enhance RNA-binding affinity and specificity, a strategy also commonly used in DNA recognition. |
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