bcr/abl嵌合基因与白血病分子机制

bcr/abl嵌合基因是白血病ph染色体的分子基础,其表达的融合蛋白具有活跃的酪氨酸激酶活性,它与细胞信号传导功能有关的蛋白作用干扰细胞正常信号的传导,影响细胞生长或凋亡。bcr/abl在白血病中的作用机制的进一步阐明有助于白血病的治疗。

The chimeric bcr/abl gene and molecular mechanism of leukemia

The chimeric bcr/abl gene is a molecular basic of leukemia with Ph Chromosome,it expresses chimeric proteins(P bcr/abl 210 and P bcr/abl 190 ) with high tyrosine kinase activity bind and phosphorylat some cell signalling proteins and affect cell amplification and/or apoptosis,The bcr/abl gene can transform hematopoietic cell easily,and It is not clear why in some circumstances bcr/abl cause chronic leukemia and in others acute leukimia.Hopefully,better understanding of mechanisms of bcr/abl induced transformation will produce more effective treatment of leukemia.;