| 双哌达莫促肺泡巨噬细胞抗病毒作用 |
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| 引用本文： | 楼皖玲,潘家华,陈兰举,丁周志.双哌达莫促肺泡巨噬细胞抗病毒作用[J].中国组织化学与细胞化学杂志,1999(3). |
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| 作者姓名： | 楼皖玲 潘家华 陈兰举 丁周志 |
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| 作者单位： | 安徽蚌埠医学院组织胚胎学教研室!附院儿科，蚌埠233004，安徽蚌埠医学院组织胚胎学教研室!附院儿科，蚌埠233004，安徽蚌埠医学院组织胚胎学教研室!附院儿科，蚌埠233004，安徽蚌埠医学院组织胚胎学教研室!附院儿科，蚌埠233004 |
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| 摘 要： | 观察双哌达莫 （ＤＰＭ） 对呼吸道合胞病毒 （ＲＳＶ） 肺炎小鼠肺泡巨噬细胞 （Ａｍ ） 的作用。采用组织化学和电镜等方法， 对肺炎组与肺炎＋ ＤＰＭ 处理组进行了对比观察。结果显示肺炎组Ａｍ 超微结构发育不良， 吞噬与分泌能力弱； ＤＰＭ 处理组比肺炎组Ａｍ 数量轻度增加， 细胞内溶酶体、滑面内质网与线粒体丰富，吞噬消化、分泌能力增强，病毒滴度与ＲＮＡ阳性细胞明显减少（Ｐ＜ ００１ 与Ｐ＜ ００５）。ＤＰＭ 提高Ａｍ非特异性免疫功能
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| 关 键 词： | 双哌达莫 肺泡巨噬细胞 呼吸道合胞病毒 超微结构 小鼠 |
DIPYRIDAMOLE PROMOTES THE ANTIVIRUS ABILITY OF ALVEOLAR MACROPHAGE |
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| Lou Wanlin,Pan Jiahua ,Chen Lianjiu ,et al..DIPYRIDAMOLE PROMOTES THE ANTIVIRUS ABILITY OF ALVEOLAR MACROPHAGE[J].Chinese Journal of Histochemistry and Cytochemistry,1999(3). |
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| Authors: | Lou Wanlin Pan Jiahua Chen Lianjiu |
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| Institution: | Lou Wanlin,Pan Jiahua *,Chen Lianjiu *,et al. |
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| Abstract: | The effect of dipyridamole (DPM) on alveolar macrophages (Am) of respiratory syncytial virus (RSV) pneumonia in mice was observed. The pathologic changes of the lung tissue was comparatively observed with histochemistry and transmission electron microscope in DPM treated group with RSV pneumonia and pneumonia group. The results showed Am of pneumonia group was poorly developed, the ability of phagocytosis and secretion was weak. The amount of Am in DPM treated group increased lightly, the presentation of cellular lysosome, agranular endoplasmic reticulum and mitochondria was abundant; the ability of phagocytosis, digestion and secretion increased. Viral titer of lung tissue and RNA positive cells decreased obviously as compared with pneumonia group (P<0 01 and P<0 05). These findings suggest that DPM improves Am function of non special immunity. |
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| Keywords: | Dipyridamole \ Alveolar macrophage \ Respiratory syncytial virus \ Ultrastructure \ mice |
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