Lipoic acid and diabetes II: Mode of action of lipoic acid |
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Authors: | V M Gandhi S S Wagh C V Natraj K K G Menon |
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Institution: | (1) Hindustan Lever Research Centre, Andheri (East), 400099 Bombay, India |
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Abstract: | Intraperitoneal administration of lipoic acid (10 mg/100 g) does not effect changes in serum insulin levels in normal and
alloxan diabetic rats, while normalising increased serum pyruvate, and impaired liver pyruvic dehydrogenase characteristic
of the diabetic state. Dihydrolipoic acid has been shown to participate in activation of fatty acids with equal facility as
coenzyme A. Fatty acyl dihydrolipoic acid however is sparsely thiolyzed to yield acetyl dihydrolipoic acid. Also acetyl dihydrolipoic
acid does not activate pyruvate carboxylase unlike acetyl coenzyme A. The reduced thiolysis of Β-keto fatty acyl dihydrolipoic
acid esters and the lack of activation of pyruvic carboxylase by acetyl dihydrolipoic acid could account for the antiketotic
and antigluconeogenic effects of lipoic acid |
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Keywords: | Lipoic acid diabetes acetyl coenzyme A acetyl dihydro lipoic acid fatty acid oxidation gluconeogenesis |
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