Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis |
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| Authors: | H Tonoike F Kametani A Hoshi T Shinoda T Isobe |
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| Affiliation: | 1. Department of Chemistry, Tokyo Metropolitan University, Setagaya-ku, Tokyo 158, Japan;2. Department of Medicine, Kobe University, Chuo-ku, Kobe 650, Japan |
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| Abstract: | The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG-84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the V lambda II subgroup. |
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