Mechanosensitivity of mouse tracheal ciliary beat frequency: roles for Ca2+, purinergic signaling, tonicity, and viscosity |
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| Authors: | Winters Scot L Davis C William Boucher Richard C |
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| Affiliation: | Department of Medicine, Cystic Fibrosis/Pulmonary Research and Tteatment Center, University of North Carolina, Chapel Hill, NC 27599-7248, USA. scot_winters@med.unc.edu |
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| Abstract: | Mechanosensitivity is hypothesized to participate in the regulation of ciliary beat frequency (CBF) in airway epithelia. To investigate this hypothesis, CBF in excised mouse trachea was monitored (microscopy image analysis) while varying mucosal shear (perfusate velocity and/or viscosity; planar flow). CBF increased within minutes of step increase to steady shear stress as small as 10(-3) Pa and decreased within minutes of shear reduction (
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