New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities |
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| Authors: | Schenone Silvia Brullo Chiara Bruno Olga Bondavalli Francesco Ranise Angelo Filippelli Walter Rinaldi Barbara Capuano Annalisa Falcone Giuseppe |
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| Institution: | Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it |
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| Abstract: | Two series of N-5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low. |
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