Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver. |
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| Authors: | K Y Hostetler |
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| Institution: | Department of Medicine, University of California, San Diego. |
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| Abstract: | Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase. |
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