THE GAUCHER MOUSE: ADDITIONAL BIOCHEMICAL ALTERATIONS |
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Authors: | M C Stephens A Bernatsky G Legler J N Kanfer |
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Institution: | Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, R3E OW3 |
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Abstract: | Abstract— Additional biochemical alterations were observed in the Gaucher mouse. The activity of β-xylosidase in brain, spleen and liver was considerably decreased in this animal model and acid phosphatase in plasma was increased about 4-fold. The levels of the splenic hexosylceramides, glucosyl-ceramide, lactosylceramide, trihexosylceramide, globoside and hematoside were all increased in comparison with controls. Brain ganglioside content was examined and very few differences were noted; however, there was a tendency towards slight elevations for the monosialogangliosides and GD1a and lower values for GD1b and GT. |
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