Stereoselective intramolecular cyclization to 4-(hydroxymethyl)-3-(1H-indolyl)oxazolidin-2-ones |
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Authors: | Chiummiento Lucia Funicello Maria Tramutola Francesco |
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Affiliation: | Dipartimento di Chimica A. M. Tamburro, Università degli Studi della Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy. |
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Abstract: | A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1H-indolyl)oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2-ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very interesting building blocks in drug synthesis. |
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Keywords: | heterocycles building block indolyloxazolidinones antibacterial organic synthesis |
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