WNT-mediated relocalization of dishevelled proteins |
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| Authors: | Susan A Steitz Michael Tsang Daniel J Sussman |
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| Institution: | (1) Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201 Baltimore, Maryland |
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| Abstract: | Summary TheWnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. TheDrosophila Wnt homolog, thewingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved
through evolution. One such element, thedishevelled gene product, becomes hyperphosphorylated and translocates to the plasma membrane in response to Wg (Yanagawa et al., 1995).
We report here that the mouseDishevelle-1 (Dvl-1) andDishevelled-2 genes encode proteins that are differentially localized inWnt-overexpressing PC12 cell lines (PC12/Wnt). WhereasDvl-1 andDvl-2 proteins are limited to the soluble fraction of parental PC12 cells, PC12/Wnt cells display a subset ofDvl-1 protein associated with the membrane andDvl-2 protein with the cytoskeletal fraction. These results suggest a conserved role forDvl inWnt/wg signal transduction. |
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| Keywords: | Dishevelled Wnt signaling PC12 cells signal transduction |
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