Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules |
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Authors: | Wang W Préville P Morin N Mounir S Cai W Siddiqui M A |
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Institution: | BioChem Pharma Inc., Laval, Québec, Canada. wangwu@biochempharma.com |
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Abstract: | An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. |
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