DNA nanotubes as combinatorial vehicles for cellular delivery |
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Authors: | Ko SeungHyeon Liu Haipeng Chen Yi Mao Chengde |
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Affiliation: | Purdue University, Department of Chemistry, West Lafayette, Indiana 47907, USA. |
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Abstract: | This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells as demonstrated by fluorescence imaging and fluorescence-activated cell sorting. No obvious toxicity has been observed under current experimental conditions. |
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