Photo-regulation of DNA/RNA duplex formation by azobenzene-tethered DNA towards antisense strategy. |
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| Authors: | X Liang T Yoshida H Asanuma M Komiyama |
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| Affiliation: | Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguroku, Tokyo 153-8904, Japan. |
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| Abstract: | Modified DNA carrying an azobenzene was successfully applied to the photo-regulation of DNA/RNA hybridization. When the azobenzene was isomerized from trans- to cis-form on UV-irradiation, the melting temperature of the duplex was significantly lowered. This process was totally reversible so that the Tm increased by cis-->trans isomerization induced by visible light irradiation. |
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