Function of caspase-14 in trophoblast differentiation |
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| Authors: | Lloyd J White Wim Declercq Frank Arfuso Adrian K Charles Arun M Dharmarajan |
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| Affiliation: | (1) Faculty of Life and Physical Sciences, School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Hwy Crawley, Perth, 6009 Western Australia, Australia;(2) Department of Molecular Biology, Ghent University, Technologie Park 927, B-9052 Ghent, Belgium;(3) King Edward Memorial Hospital for Women (KEMH), 374 Bagot Rd, Subiaco, 6008 Western Australia, Australia |
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| Abstract: | Background Within the human placenta, the cytotrophoblast consists of a proliferative pool of progenitor cells which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast, which forms the barrier between the maternal and fetal tissues. Disruption to trophoblast differentiation and function may result in impaired fetal development and preeclampsia. Caspase-14 expression is limited to barrier forming tissues. It promotes keratinocyte differentiation by cleaving profilaggrin to stabilise keratin intermediate filaments, and indirectly providing hydration and UV protection. However its role in the trophoblast remains unexplored. |
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