| Affiliation: | (1) Department of Biochemistry, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228-8555, Japan;(2) Division of Biology, Center for Natural Science, Kitasato University, Kanagawa 228-8555, Japan;(3) Isehara Kyodo Hospital, Kanagawa 259-1132, Japan;(4) Department of Endocrinology and Metabolism, Kitasato University School of Medicine, Kanagawa 228-8555, Japan;(5) Department of Rehabilitation, Kitasato University School of Allied Health Sciences, Kanagawa 228-8555, Japan;(6) Department of Laboratory Animal Science, Kitasato University School of Medicine, Kanagawa 228-8555, Japan;(7) Department of Bioinformatics, Faculty of Engineering, Soka University, Tokyo 192-8577, Japan;(8) Kanagawa Rehabilitation Hospital, Kanagawa 242-0121, Japan;(9) School of Medical Technology and Health, Saitama Medical College, Saitama 350-0495, Japan;(10) Tamai Kokoro Clinic, Kamakura, Kanagawa 248-0011, Japan;(11) Department of Gastroenterology, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan |
| Abstract: | Diabetic neuropathy is the most common complication of diabetes. We examined the levels and the mRNA expression of myelin proteins in the sciatic nerves and the brains of streptozotocin-induced diabetic rats. The diabetic rats exhibited a decrease in body weight, elevation of the blood glucose level and a decrease in motor nerve conduction velocity at 2 weeks after streptozotocin injection. In the sciatic nerves of diabetic rats, the level of P0 protein and its mRNA expression were markedly reduced at 20 weeks after the injection. In the brains, the levels of proteolipid protein and myelin-associated glycoprotein and their mRNA expression were selectively decreased at 20 weeks after the injection. This affected expression of myelin proteins was found even when no histological abnormalities were detectable. Considering the functional significance of myelin proteins, this impairment of protein expression is possibly involved in the pathogenesis of diabetic neuropathy, including that in brain disorders. |
