Determination of perhexiline and hydroxyperhexiline in plasma by liquid chromatography-mass spectrometry |
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| Authors: | Beck O Stephanson N Morris R G Sallustio B C Hjemdahl P |
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| Affiliation: | Department of Medicine, Division of Clinical Pharmacology, Karolinska Hospital & Institute, SE-17176 Stockholm, Sweden. olof.beck@ks.se |
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| Abstract: | A method for the quantitative determination of perhexiline and its main hydroxylated metabolites in human plasma, based on liquid chromatography-mass spectrometry (LC-MS), was developed. The method used protein precipitation with acetonitrile followed by dilution with water and subsequent direct injection of the extract into the LC-MS system. Hexadiline was used as internal standard and the intra-assay coefficients of variation were
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| Keywords: | Perhexiline Hydroxyperhexiline |
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