Biological half-time in rats exposed to nickel monosulfide (amorphous) aerosol by inhalation |
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| Authors: | Isamu Tanaka Sigeko Ishimatsu Joji Haratake Akio Horie Yasushi Kodama |
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| Institution: | (1) Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan;(2) Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, 807 Yahatanishi, Kitakyushu, Japan;(3) Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, 807 Yahatanishi, Kitakyushu, Japan |
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| Abstract: | This study reports the biological half-time of amorphous nickel monosulfide(NiS(A)) aerosol retained in rat lungs. Wistar
male rats were exposed to NiS(A) aerosols (mass median aerodynamic diameter: 4.0 μm) for a single 4 h exposure, or for 7 h/d,
5 d/wk for 1 mo. The average exposure concentrations were controlled at 107 mg/m3 for the single exposure and at 8.8 mg/m3 for the repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw
feeder. After the exposures, the nickel contents in the rat organs, blood, and urine were measured and histopathological examinations
were performed. The biological half time of NiS(A) in rat lungs was 20 h, which was extremely shorter than 21 mo of green
nickel oxide (NiO(G)). There were no malignant tumors in any of the exposure groups. |
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| Keywords: | Pulmonary deposition and clearance nickel monosulfide inhalation toxicity health effect biological half time histopathological examination |
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