Salvianolic Acid A Exerts Antiamnesic Effect on Diazepam-Induced Anterograde Amnesia in Mice |
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Authors: | T Wang S Y Shan B Han L M Zhang F H Fu |
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Institution: | (1) Department of Pharmacology, School of Pharmacy, Yantai University, 32#, Qingquan Road, Yantai, 264005, People’s Republic of China;(2) School of Foreign Languages, Yantai University, 32#, Qingquan Road, Yantai, 264005, People’s Republic of China; |
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Abstract: | Benzodiazepine was known to produce amnesia. Salvianolic acid A extracted from Salvia miltiorrhiza was an effective antioxidant. The objective of the study was to evaluate the effect of salvianolic acid A on diazepam-induced
amnesia in mice. C57BL/6 mice were treated with salvianolic acid A at doses of 10, 20 and 40 mg/kg following administration
with diazepam at a dose of 3 mg/kg. Morris water maze was performed to evaluate the effect of salvianolic acid A on amnesia.
The antioxidative parameters in hippocampus were measured. The results showed that salvianolic acid A decreased the mean escape
latency and increased the percentage of time spent in target quadrant. Salvianolic acid A reduced the content of malondialdehyde
and increased the activities of superoxide dismutase, catalase and glutathione peroxidase in hippocampus. The findings demonstrated
that salvianolic acid A had antiamnesic effects on diazepam-induced anterograde amnesia in mice, by augmenting the antioxidative
capacity of hippocampus. |
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