Effect of Treadmill Exercise on Blood Glucose,Serum Corticosterone Levels and Glucocorticoid Receptor Immunoreactivity in the Hippocampus in Chronic Diabetic Rats |
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| Authors: | In Koo Hwang Sun Shin Yi Ki-Yeon Yoo Ok Kyu Park Bingchun Yan Wook Song Moo-Ho Won Yeo Sung Yoon Je Kyung Seong |
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| Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute For Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Biomedical Sciences, College of Health Sciences, Marquette University, Milwaukee, WI 53233, USA;(3) Institute of Natural Medicine, Hallym University, Chuncheon, 200-702, South Korea;(4) Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(5) Institute of Sports Science, Seoul National University, Seoul, 151-742, South Korea;(6) Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea; |
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| Abstract: | Abnormal excess of glucocorticoid is one of feature characteristics in type 2 diabetes. In the present study, we investigated
the effect of treadmill exercise at chronic diabetic stages on glucocorticoid receptor (GR) immunoreactivity in the hippocampal
CA1 region and dentate gyrus, which are very vulnerable to diabetes. For this study, we used Zucker diabetic fatty (ZDF) rats
and Zucker lean control (ZLC) rats. Twenty-three-week-old ZLC and ZDF rats were put on the treadmill with or without running
for 7 weeks and sacrificed at 30 weeks of age. Treadmill exercise significantly decreased diabetes-induced blood glucose and
serum corticosteroid levels although they did not drop to control levels. In sedentary ZLC rats, GR immunoreactivity was detected
in pyramidal cells of the CA1 region as well as in granule cells of the dentate gyrus. In the sedentary ZDF rats, GR immunoreactivity
was significantly increased in these regions. However, treadmill exercise significantly decreased GR immunoreactivity in these
regions. These results indicate that treadmill exercise in chronic diabetic rats significantly decreased GR immunoreactivity
in the hippocampal CA1 region and dentate gyrus, although blood glucose and serum corticosteroid levels did not fully recover
to normal state. |
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