Comparison of Glucocorticoid Receptor and Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity in the Adult and Aged Gerbil Hippocampus Following Repeated Restraint Stress |
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| Authors: | Joon Ha Park Ki-Yeon Yoo Choong Hyun Lee In Hye Kim Bich Na Shin Jung Hoon Choi Jeong Ho Park In Koo Hwang Moo-Ho Won |
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| Institution: | (1) Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(2) Department of Oral Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung, 210-702, South Korea;(3) Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea;(4) Department of Physiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(5) Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(6) Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon, 305-719, South Korea;(7) Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea; |
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| Abstract: | Stress leads to changes in homeostasis and internal balance of the body and is known to be one of important factors in the
development of several diseases. In the present study, we investigated changes in glucocorticoid receptor (GR) and ionized
calcium-binding adapter molecule 1 (Iba-1) immunoreactivity in the adult and aged gerbil hippocampus after chronic restraint
stress. Serum corticosterone level was much higher in both the stress-groups than the control groups. No neuronal death was
found in all hippocampal subregions of the adult and aged gerbil after chronic restraint stress. GR immunoreactivity was decreased
in both the adult and aged groups after repeated restraint stress; however, GR immunoreactivity in the adult-stress-group
was decreased much more than that in the aged-stress-group. Iba-1 immunoreactive microglia were hypertrophied and activated
in the adult group after repeated restraint stress; in the aged-stress-group, there was no any significant change in Iba-1
immunoreactive microglia. In brief, level of GR, not Iba-1, in the hippocampus was much decreased in the adult gerbil compared
to the aged gerbil following chronic restraint stress. |
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