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Peptide and protein imaging mass spectrometry in cancer research |
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| Authors: | Liam A McDonnell Garry L Corthals Stefan M Willems Alexandra van Remoortere René JM van Zeijl André M Deelder |
| Institution: | 1. Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands;2. Turku Centre for Biotechnology, Tykistökatu 6, 20521 Turku, Finland;3. Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands |
| Abstract: | MALDI mass spectrometry is able to acquire protein profiles directly from tissue that can describe the levels of hundreds of distinct proteins. MALDI imaging MS can simultaneously reveal how each of these proteins varies in heterogeneous tissues. Numerous studies have now demonstrated how MALDI imaging MS can generate different protein profiles from the different cell types in a tumor, which can act as biomarker profiles or enable specific candidate protein biomarkers to be identified. |
| Keywords: | Imaging mass spectrometry MSI MALDI Cancer Biomarker Histopathology |
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