When peptides fly: Advances in Drosophila proteomics |
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Authors: | Alexey Veraksa |
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Affiliation: | Department of Biology, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA |
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Abstract: | In the past decade, improvements in genome annotation, protein fractionation methods and mass spectrometry instrumentation resulted in rapid growth of Drosophila proteomics. This review presents the current status of proteomics research in the fly. Areas that have seen major advances in recent years include efforts to map and catalog the Drosophila proteome and high-throughput as well as targeted studies to analyze protein–protein interactions and post-translational modifications. Stable isotope labeling of flies and other applications of quantitative proteomics have opened up new possibilities for functional analyses. It is clear that proteomics is becoming an indispensable tool in Drosophila systems biology research that adds a unique dimension to studying gene function. |
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Keywords: | Drosophila Proteomics Mass spectrometry Affinity purification Proteome Model organism |
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