生物质谱分析法在脂质组学的应用

脂质与许多慢性病(如糖尿病、高血压)和精神系统疾病(如阿尔茨海默病)等有关。脂质组学是以现代生物技术为手段，对生物体中的全脂质进行定性和定量的一门新兴学科。目前，生物质谱分析法是对脂质谱进行分析和定量的最有效方法，国内对脂质组学的系统研究还比较匮乏。综述脂质组学的概念与分类，探究不同的生物样品前处理方法，系统介绍近几年国际上生物质谱分析法在脂质组学的应用，并对脂质组学的发展趋势进行展望。

Application of Biological Mass Spectrometry in Lipidomics Analysis

Lipids are associated with many chronic diseases (such as diabetes and hypertension) and mental system disorders (e.g.Alzheimer’s disease). Lipidomics uses modern biotechnology to analyze biological samples. It is a new field to analyze total lipids quantitatively and qualitatively. At present, biological mass spectrometry has become the most effective method in lipid analysis. However, systematic research on lipidomics is rare in the domestic literature. Based on the available literature, an overview is provided, including classification of lipidomics, pretreatment method of biological sample, and analytical methods. Moreover, different pretreatment methods of biological samples are compared and analyzed. Simultaneously, the use of biological mass spectrometry in lipidomics is systematically introduced in recent years. In addition, the future trend of lipidomics is also introduced and analyzed.