Molecular mechanisms of developmental timing in C. elegans and Drosophila. |
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Authors: | C S Thummel |
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Institution: | Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA. carl.thummel@genetics.utah.edu |
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Abstract: | Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge. |
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