Graded Autocatalysis Replication Domain (GARD): Kinetic Analysis of Self-Replication in Mutually Catalytic Sets |
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Authors: | Segré Daniel Lancet Doron Kedem Ora Pilpel Yitzhak |
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Institution: | (1) Department of Membrane Research and Biophysics, The Weizmann Institute of Science, Rehovot, 76100, Israel |
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Abstract: | A Graded Autocatalysis Replication Domain (GARD) model is proposed, which provides a rigorous kinetic analysis of simple chemical sets that manifest mutual catalysis. It is shown that catalytic closure can sustain self-replication up to a critical dilution rate, c, related to the graded extent of mutual catalysis. We explore the behavior of vesicles containing GARD species whose mutual catalysis is governed by a previously published statistical distribution. In the population thus generated, some GARD vesicles display a significantly higher replication efficiency than most others. GARD thus represents a simple model for primordial chemical selection of mutually catalytic sets. |
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