A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins |
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| Authors: | Mats Ensterö Örjan Åkerborg Daniel Lundin Bei Wang Terrence S Furey Marie Öhman Jens Lagergren |
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| Affiliation: | 1.Department of Molecular Biology and Functional Genomics,Stockholm University,Stockholm,Sweden;2.Stockholm Bioinformatics Centre (SBC),Stockholm University,Stockholm,Sweden;3.School for Computer Science and Communication (CSC),Royal Institute of Technology (KTH),Stockholm,Sweden;4.Deptartment of Biostatistics and Bioinformatics,Institute for Genome Sciences and Policy (IGSP),USA;5.Department of Computer Science,Duke University,Durham,USA |
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| Abstract: | Background Several bioinformatic approaches have previously been used to find novel sites of ADAR mediated A-to-I RNA editing in human. These studies have discovered thousands of genes that are hyper-edited in their non-coding intronic regions, especially in alu retrotransposable elements, but very few substrates that are site-selectively edited in coding regions. Known RNA edited substrates suggest, however, that site selective A-to-I editing is particularly important for normal brain development in mammals. |
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