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Bortezomib Inpatient Prescribing Practices in Free-Standing Children's Hospitals in the United States
Authors:Amanda M. DiNofia  Elizabeth Salazar  Alix E. Seif  Yimei Li  Yuan-Shung Vera Huang  Rochelle Bagatell  Brian T. Fisher  Richard Aplenc
Abstract:This study is a pharmacoepidemiologic description of pediatric bortezomib use. Exposure was identified through billing codes in patients admitted to US children’s hospitals that participated with the Pediatric Health Information System between 2004 and 2013. Associated information on underlying diseases, demographics, institutional use, mortality, and physician type was collected. Exposure to bortezomib was identified in 314 patients. Hematologist/Oncologists prescribed half of the bortezomib used. Use increased during the study period. Inpatient volume was positively correlated with bortezomib utilization. Bortezomib use in pediatrics is increasing for a variety of diseases. Variation in use exists across institutions. Further studies are needed to characterize bortezomib’s efficacy in pediatric diseases.
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