首页 | 本学科首页   官方微博 | 高级检索  
     


A serum test for cystic fibrosis using monoclonal antibody 19-9
Authors:D D Roberts  D L Monsein  R C Frates  M S Chernick  V Ginsburg
Affiliation:1. Laboratory of Structural Biology, NIADDK, National Institutes of Health, Bethesda, Maryland 20892 U.S.A.;2. Laboratory of Cell Biology and Genetics NIADDK, National Institutes of Health, Bethesda, Maryland 20892 U.S.A.;3. Pediatric Metabolism Branch, NIADDK, National Institutes of Health, Bethesda, Maryland 20892 U.S.A.;1. Department of Thoracic Head & Neck Medical Oncology;2. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston;3. Department of Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore;4. Department of Thoracic and Cardiovascular Surgery;5. Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA;1. Department of Pathology and Molecular Medicine, Division of Clinical Pathology, McMaster University, Canada;2. Department Medicine, Division of Cardiology, McMaster University, Canada;3. Department Medicine, Division of Emergency Medicine, McMaster University, Canada;1. School of Social Work, University of North Carolina at Chapel Hill, United States;2. Department of Criminal Justice, The College at Brockport, State University of New York, United States;3. College of Social Work, University of South Carolina, United States;1. Department of Surgery, University of Oklahoma College of Medicine, Oklahoma City, OK, USA;2. Department of Anesthesiology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA;3. OU Medical Center, Oklahoma City, OK, USA;4. Department of Orthopedic Surgery, University of Oklahoma College of Medicine, Oklahoma City, OK, USA;1. Department of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, Taiwan;2. Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan;3. Division of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan;4. Department of Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan;5. Department of Surgery, Asia University Hospital, Taichung, Taiwan;6. Department of Internal Medicine, E-DA Hospital, Kaohsiung, Taiwan;7. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Abstract:Monoclonal antibody 19-9 detects a sialosylated Lea antigen with the following sugar sequence: NeuNAc alpha 2-3Gal beta 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal. . . . This antigen is detected as a mucin in the sera of many patients with gastrointestinal and pancreatic cancer. Elevated levels of sialosylated Lea antigen are also detected in serum from 14 of 16 patients with cystic fibrosis (87%). One of the two negative patients belongs to the Le(a-b-) blood group and so is unable to synthesize the sialosylated Lea antigen. The high percentage of cystic fibrosis patients with elevated sialosylated Lea antigen suggests that the 19-9 antibody may be useful for diagnosis of cystic fibrosis. Antibodies to other sialosylated carbohydrates in mucins may also be useful for detection of cystic fibrosis and may allow diagnosis of patients belonging to the Le(a-b-) blood group.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号