Mutants of Escherichia coli with temperature-sensitive lesions in membrane phospholipid synthesis: genetic analysis of glycerol-3-phosphate acyltransferase mutants |
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| Authors: | John E Cronan Jr and G Nigel Godson |
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| Institution: | (1) Department of Molecular Biophysics, Yale University, 06510 New Haven, Connectict;(2) Department of Biochemistry, Yale University, 06510 New Haven, Connectict;(3) Radiology Laboratory, Yale University, 06510 New Haven, Connectict;(4) Radiobiology Laboratory, Yale University, 06510 New Haven, Connectict |
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| Abstract: | Summary
Escherichia coli mutants possessing temperature-sensitive lesions in glycerol-3-phosphate acyltransferase, the enzyme catalysing the first step in phospholipid biosynthesis, have been characterized genetically. By recombinational and complementation tests, the mutants have been found to map in a single locus, called plsA, which is cotransducibile with the purE locus and lies between the purE and proC loci at minute 13 on the E. coli genetic map. |
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