Liposomal membranes. XIV. Fusion of liposomal membranes induced by polyisoprenoids as monitored by fluorescence quenching method |
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Authors: | J Sunamoto K Iwamoto T Tezuka K Kadosaki H Kondo |
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Institution: | Department of Industrial Chemistry, Faculty of Engineering, Nagasaki University, Nagasaki 852 Japan |
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Abstract: | Fusion of the single-walled liposomes of egg phosphatidylcholine as induced by the polyisoprenoids such as solanesol, trans-ethyl decaprenoate (EDP), coenzyme Q10, and dolichol has been investigated adopting the fluorescence quenching method. Relative efficiency of the polyisoprenoids employed on the induced fusion of liposomes was a sequence of solanesol less than or equal to EDP much less than CoQ10, dolichol, which was consistent with the result previously obtained by the dye-release method. |
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Keywords: | mechanism of liposome fusion drug-induced fusion of liposome fluorescence quenching technique |
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